摘要
目的探讨血管内皮生长因子(vascularendothelialgrowthfactorVEGF)在肝癌经肝动脉栓塞化疗(transcatheterhepaticarterialchemoembolizationTACE)术后复发和转移中的作用。方法选取经TACE治疗后2期切除的肝癌标本29例,以同期单纯手术切除的30例标本作为对照,采用免疫组织化学和图像分析的方法检测VEGF的表达。结果TACE治疗组与单纯手术组的VEGF吸光度值分别为(0.149±0.021)和(0.134±0.018),前者明显高于后者(P<0.05)。结论VEGF的高表达可能是引起TACE术后高复发和转移率的一个重要原因。
[Objective] To investigate the role of vascular endothelial growth factor （VEGF） in recurrence and metastasis of hepatocellular carcinoma （HCC） after transcatheter hepatic arterial ehemoembolization （TACE）. [Methods] The expression of VEGF in 29 HCC samples obtained from the patients undergoing secondary hepateetomy after TACE was examined by immunohistoehemieal staining and morphometrie analysis. 30 HCC samples obtained from the patients without TACE were examined as the control group. [Results] The VEGF expressions in the TACE group was higher than that of the control group （P 〈0.05）. [Conclusion] The high expressions of VEGF is possibly an important reason of high recurrence and metastasis of HCC after TACE.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第17期2647-2649,共3页
China Journal of Modern Medicine
关键词
血管内皮生长因子
肝癌
经肝动脉栓塞化疗术
vascular endothelial growth factor, hepatocelltdar carcinoma
transcatheter hepatic arterial chemoembolization
