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冷冻干燥对提高脂质体稳定性的研究概况 被引量：32

Profiles in Improvements of Liposomes Stability by Freeze-drying
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摘要 讨论了脂质体在冷冻干燥、复水化及贮存过程中的稳定性,并介绍了冻干保护剂的作用机理。 The stability of liposomes during freeze-drying, rehydration, storage and the mechanism of the lyoprotectants are discussed.
作者 王健 李明轩
机构地区 上海新药研究开发中心
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2005年第9期576-580,共5页 Chinese Journal of Pharmaceuticals
关键词 脂质体 冷冻干燥 稳定性 综述 liposome freeze-drying stability review
分类号 R944.9 [医药卫生—药剂学]
  • 相关文献

参考文献30

  • 1Miyajima K. Role of saccharides for the freeze-thawing and freeze-drying of liposome [J]. Adv Drug Deliv Rev, 1997, 24(2,3): 151-159.
  • 2Crowe LM, Crowe JH, Rudolph A, et al. Preservation of freezedried liposomes by trehalose [J]. Arch Biochem Biophys, 1985,242(1): 240-247.
  • 3Bridges PA, Taylor KMG. The effects of freeze-drying on the stability of liposomes to jet nebulization [J]. J Pharm Pharmacol, 2001, 53 (3): 393-398.
  • 4Tanaka K, Takeda T, Fujii K, et al. Cryoprotective mechanism of saccharides on freeze-drying of liposome [J]. Chem Pharm Bull, 1992,40 (1): 1-5.
  • 5van Winden ECA, Crommelin DJA. Long term stability of freeze-dried, lyoprotected doxorubicin liposome [J]. Eur J Pharm Biopharm, 1997, 43 (3): 295-307.
  • 6Ausborn M, Schreier H, Brezesinski G, et al. The protective effect of free and membrane-bound cryoprotectants during freezing and freeze-drying of liposomes [J]. J Controlled Release, 1994, 30 (2): 105-116.
  • 7Suzuki T, Komatsu H, Miyajima K. Effects of glucose and its oligomers on the stability of freeze-dried liposomes [J].Biochim Biophys Acta, 1996,1278 (2): 176-182.
  • 8Ozaki K, Hayashi M. The effects of glucose oligomers (maltodextrins) on freeze-drying liposomes [J]. Chem Pharm Bull (Tokyo), 1997,45 ( 1 ): 165 - 170.
  • 9Ozaki K, Hayashi M. Cryoprotective effect of cycloinulohexaose on freezing and freeze-drying of liposomes [J].Chem Pharm Bull(Tokyo), 1996,44(11): 2116-2120.
  • 10Ozaki K, Hayashi M. Effect of cycloinulohexaose with additives on the freeze-drying of liposome [J]. Int J Pharm, 1998,160 (2): 219-227.

二级参考文献4

  • 1Arsic I,Vidovic S,Vuleta G.Influence of liposomes on the stability of vitamin A incorporated in polyacrylate hydrogel[J].Int J Cosmet Sci,1999,21(4):219-225.
  • 2Singh AK,Das J.Liposome encapsulated vitamin A compounds exhibit greater stability and diminished toxicity[J].Biophys Chem,1998,73(1-2):155-162.
  • 3Payne N,Timmins P,Ambrose CV,et al.Proliposomes: a novel solution to an old problem[J].J Pharm Sci,1986,75(4):325-329.
  • 4刘占杰,华泽钊,陈建明,高申.药品冷冻干燥过程中的玻璃化作用[J].中国医药工业杂志,2000,31(8):380-383. 被引量：24

共引文献18

同被引文献393

引证文献32

二级引证文献114

中国医药工业杂志
2005年 第9期

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