摘要
30例行心脏直视术患者随机分为对照组和抑肽酶用药组。于肝素化前、肝素化后10分钟、给鱼精蛋白前、给鱼精蛋白后10分钟,分别观察 ACT、血小板计数、血小板聚集率、肺动脉平均压、肺血管阻力、TXB_2的变化。结果表明:心脏直视术中大剂量抑肽酶对肝素的抗凝有协同作用,但不影响鱼精蛋白对肝素的拮抗,其机制与保护血小板功能有关。同时抑肽酶可减轻鱼精蛋白应用后的肺血管阻力增加和肺动脉压升高,其机制可能与其能减少鱼精蛋白导致的 TXB_2升高有关。
Thirty patients undergoing open-heart operations were fall into two groups (control and aprotinin groups).The platelet counts,platelet aggregation function,thromboxane B2,mean pulmonary arterial pressure (MPAP),pulmonary vascular resistence (PVR)were detected before heparization, ten minutes after heparization,before protamin administra- tion and ten minutes after protamin administration.The result showed that high-dose aprotinin had active effect on heparin,but it didn't affect the heparin resersal with pro- tamin.The mechanism is that the aprotinin may protect the function of platelets.And the Aprotinin also may reduce the increased plasma TXB2 level and inceased MPAP,PVR, which were induced after the use of protamin.
出处
《中国胸心血管外科临床杂志》
CAS
1996年第1期14-16,共3页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
