摘要
为探讨更年期情感障碍妇女去甲肾上腺素(NE)系统功能及其与内分泌改变的关系,作者测定10例正常和20例情感障碍的更年期妇女的血浆 NE 含量(高效液相色谱法)和血清卵泡刺激素(FSH)、黄体生成激素(LH)、雌二醇(E_2)水平(RIA 法)。结果显示更年期情感障碍妇女血浆 NE 显著高于正常更年期妇女,且随病情好转,NE 有回落趋势。两组间 FSH、LH、E_2水平无显著性差异。提示更年期情感障碍者的 NE 系统功能变化与内源性抑郁症相一致;E_2降低对更年期情感障碍的发病似乎不起直接作用。
In this study,the plasma norepinephrine (NE) levels were measured using HPLC-ED and serum FSH,LH and E_2 concentrations were determined using RIA in 20 women with menopausal mood disturbance and 10 normal menopause women.The results:showed that the patients with menopausal mood disturbance (MMD) had significantly higher level of plasma NE than normal menopausal women (176+24,vs 108±17ng/L,+s_,P<0.05).With the improvement of the clinical features,of menopausal mood disturbance,the levels of NE fell relatively,from 204+39 to 138+23ng/L(+s_,P>0.05).There were no significant difference in the levels of FSH,LH and E_2 between the women with MMD and those with menopause but without mood disturbance.This suggested that the changes of norepinephrine systematic function in MMD women were consistent with that in the endogenous depression patients.There was no evidence to support the decrease of estradiol(E_2)level in association with MMD.
出处
《中华精神科杂志》
CAS
CSCD
1996年第1期39-42,共4页
Chinese Journal of Psychiatry
