摘要
研究Ｍｇ２＋对脑缺血大鼠血浆及脑组织ＥＴ－１含量的影响，进一步探讨Ｍｇ２＋保护缺血神经元的机制。方法用双侧颈总动脉结扎法建立大鼠脑缺血模型，用ＲＩＡ法测定注射Ｍｇ２＋前后脑缺血大鼠血浆及脑组织中ＥＴ－１含量。结果Ｍｇ２＋可降低脑缺血时血浆及脑组织中ＥＴ－１的含量。结论Ｍｇ２＋通过降低脑缺血时增高的ＥＴ－１，起到保护缺血神经元的作用。
Objective To study the effect of magnesium ion on endothelin-1(ET-1) levels in plasma and brain tissue of rats with cerebral ischemia. So as to investigate the mechanism of protecting ischemic neuron of magnesium ion. Methods We established rat cerebral ischemia models of bilateralcarotid communis artery occlusion with ligation,determined the leves of ET-1 in plasma and brain tissueof rats with cerebral ischemia before and after injection Mg2+ by RIA. Results This study showed thatmagnesium ion can decrease the levels in plasma and brain tissue of rats with cerebral ischemia. Conclusion The results implied that magnesium ion can protect the ischemic neurons through decreasing theincreased ET-1 with cerebral ischemia.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
1999年第1期6-8,共3页
Journal of Apoplexy and Nervous Diseases
