摘要
体外培育牛黄２００～８００ｍｇ／ｋｇ，ｉｇ５～７天，可显著抑制小鼠巴豆油性耳廓水肿，大鼠角叉菜胶性足肿胀，大鼠巴豆油肉芽囊肿的渗出和组织增生，抑制白细胞游走反应，对抗ＰＧＥ２致毛细血管通透性增加，但不影响肾上腺中ＶｉｔＣ含量，本品抗炎作用强度与牛黄相似。
Cultured calculus bovis(CCB)200 ～800mg/kg ig for 5～7 days can markedly inhibit acuteand chronic inflammation, including the mouse ear edema produced by croton oil,the swelling of rat pawcaused by carrageenin,the exudation and granulomatosis caused by croton oil in rats, the leucocyte migra-tory response caused by carboxymethyl cellulose, and the increase of capillary permeability induced byPGE2. It did not reduce the content of Vit C of adrenal glands in rats. The potency of the anti-inflamma-tory action of CCB is equal to that of calculus bovis.
出处
《中药新药与临床药理》
CAS
CSCD
1996年第1期27-29,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
中药
体外培育牛黄
药理学
抗炎作用
cultured calculus bovis/pharmacology
inflammation/therapy, TCM
