摘要
目的:探讨老年不稳定性心绞痛(UA)患者血管性血友病因子(vWF)与可溶性血管细胞间粘附分子-1(sVCAM-1)水平变化及其与心肌缺血的关系。方法:采用酶联免疫吸附法(ELISA),检测了50例健康人和73例UA(自发性心绞痛27例,心肌梗死后心绞痛25例,恶化劳力性心绞痛21例)患者血浆vWF、sVCAM-1浓度的变化。结果:①UA患者血浆vWF水平、sVCAM-1浓度[(2.47±0.88)%、(1.92±0.51)%、(961±58)μg/L、(692±73)μg/L],明显高于对照组[(572±58)μg/L、(0.96±0.14)%](P<0.01);②心绞痛发作时vWF、sVCAM-1浓度增高较缓解后更明显(P<0.01);③心绞痛发作时和缓解后,sVCAM-1与vWF呈正相关(r=0.785,r=0.674,P<0.01);④不同类型的心绞痛发作时和缓解后sVCAM-1、vWF浓度差异亦具有显著性(P<0.01);⑤自发性心绞痛患者vWF、sVCAM-1增高较心肌梗死后和恶化劳力性心绞痛更明显。结论:急性心肌缺血与vWF和sVCAM-1异常有一定关系。
AIM： To explore the changes of von Willebrand factor （vWF） and soluble vascular- cellular adhesion molecule- 1 （sVCAM- 1）, and the correlation of vWF, sVCAM- 1 with acute myocardial ischemia. METHODS： By means of enzyme linked immunosorbent assay （EIJSA）, the changes of vWF and sVCAM - 1 were measured in 73 patients with unstable angina （UA） during angina attack and relief period （24 h after attack） as well as in 50 controls. RESULTS： The levels of vWF and sVCAM - 1 were significantly higher in UA patients than those in controls （ P 〈 0.01 ）. The increase in vWF and sVCAM - 1 in angina attack was more obvious than those in relief period （ P 〈 0.01 ）. vWF correlated positively with sVCAM - 1 （ r = 0.785, r = 0.674, P 〈 0.01 ）. In different types of angina, there were significant difference of vWF, sVCAM - 1 between angina attack and relief periods （ P 〈 0.01 ）, and increases in all the indicators in spontaneous angina patients were more obvious than those in exertional and postinfarction angina patients. CONCLUSION： Acute myocardial ischemia might be related to the changes of vWF and sVCAM- 1.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2005年第9期1717-1719,共3页
Chinese Journal of Pathophysiology
