摘要
目的观察三氧化二砷(As2O3)对人胃癌细胞株nm23、P53基因表达的影响。方法以As2O3作用于体外培养的人胃癌细胞株,通过免疫组化技术对nm23和P53基因编码蛋白的表达进行检测。结果经As2O3作用的人胃癌细胞株nm23、P53基因编码蛋白表达减少(P<0.05)。结论As2O3具有下调nm23、P53基因编码蛋白表达作用。
Objective To detect the effect arsenic trioxide （As2O3） on the expressions of human gastric cancer genes nm23 and P53. Methods The expressions of proteins coded by nm23 and P53 were examined with immunohistochemistry method after treated by AszOs. Results The expressions of proteins coded by nm23 and P53 decreased after treated by AszOs （ P 〈 0. 05 ）. Conclusion Asz Os can down-regulate the expressions of proteins coded by nm23 and P53.
出处
《中国康复理论与实践》
CSCD
2005年第8期626-627,共2页
Chinese Journal of Rehabilitation Theory and Practice
