摘要
三氧化二砷(arsenictr ioxide,As2O3),中药名为砒霜,在临床上的应用有悠久的历史.经过多年的实验室研究和临床应用,As2O3在抗肿瘤方面有确切的疗效,他是治疗急性早幼粒细胞白血病的有效药物之一,且不良反应较小,其主要机制为诱导细胞凋亡.目前As2O3已用于多种实体肿瘤的治疗,且在消化系肿瘤如肝癌的临床治疗中,疗效确切.近年来,在消化系统肿瘤的体外细胞系和体内动物模型的研究中均发现,As2O3能够诱导胃癌、胰腺癌、肝癌和结肠癌细胞凋亡,同时对癌细胞的生长起抑制作用.因此,研究As2O3在消化系恶性肿瘤防治中的作用具有重要意义.本文结合国内外文献对As2O3在治疗消化系恶性肿瘤中的作用作一综述.
Arsenic trioxide （As203）, also named arsenic, is a main ingredient of numerous traditional Chinese herbal recipes and has a long history of clinical application. It has positive anticancer effects and is effective in treating acute promyelocytic leu kemia without toxic and side effects. AS203 can induce apoptosis of cancer cells. In recent years, it has been found that AsaO3 has an apoptosis promoting effect on tumor cells in many human solid tumors, including liver cancer. Many in vitro and in vivo studies using digestive tract tu mor cell lines or animal model have found that AS203 can induce apoptosis and inhibit growth of digestive tract cancer cells. Therefore, AS203 may have an important role in the prevention of malignant tumors of the digestive system. In this article, we discuss the possible cellular and molecular mechanisms by which As203 induces apoptosis of digestive tract cancer cells.
出处
《世界华人消化杂志》
CAS
北大核心
2012年第28期2691-2696,共6页
World Chinese Journal of Digestology
关键词
三氧化二砷
消化系肿瘤
凋亡
转移
多药
耐药性
端粒酶
Arsenic trioxide
Digestive system tu-mors
Apoptosis
Metastasis
Multidrug resistance
Telomerase
