摘要
采用免疫组织化学方法对53例胰腺癌、5例癌旁胰腺导管上皮不典型增生、11例胰腺内分泌肿瘤进行癌基因产物P_21表达的研究。结果发现:P_21阳性表达率分别为88.7%、100%和9%。胰腺癌中P_21弥漫阳性表达者较局限或片状阳性表达及阴性表达者预后好(P<0.01)。结果提示ras癌基因突变在胰腺癌早期发生中起重要作用,P_21表达与否及表达类型可作为胰腺癌预后的指标。
Expression of ras oncogene p21 was in- vestigated in 53 cases of pancreatic adenocarci- noma, 5 cases of peri-cancerous ductal epitheli- a cell atypia and 11 cases of endocrine tumor by using immunohistochemical method. The positive rate were 88.7%, 100% and 9% re- spectively. Patients with diffused immuno- staining for ras-p21 oncoprotein were correlat- ed with a better prognosis than those of non- diffused and non-expressed cases. Our data demonstrates that the mutation of ras onco- gene plays an important role in the early de- velopment of pancreatic cancer,and the type of expression appears to be one of the prognostic molecular markers in patients with pancreatic cancer.
出处
《中华实验外科杂志》
CSCD
北大核心
1996年第1期27-28,共2页
Chinese Journal of Experimental Surgery
