摘要
山莨菪碱对烫伤大鼠心肌的保护作用秦卫军姚秀娟孙向东陈水英梅其柄赵德化（第四军医大学药理教研室，西安７１００３２）近年来文献报道严重烫伤后心血管功能及结构方面有很大改变，这往往是加重烧伤休克而导致多脏器衰竭的重要原因之一［１］．故烫伤早期补液的同时保护...
Effect of anisodamine (Ani) on myocardial injury after burn was observed in rats inflicted with burn of Ⅲ degree on 30% total body surface area (TBSA). Ani 1, 5 and 10 mg·kg -1 was given every 4 h ip after burn injury. lt was found that Ani significantly decreased the release of creatine phospokinase, lactate dehydrogenase and malondialdehyde content,inhibited phospholipase A 2 (PLA 2) activity and also increased superoxide dismutase activity 12 h after burn. The results suggested that the protective mechanism of Ani on myocardium after burn injury might be related to membrane stabilization through antilipid peroxidation and PLA 2 activity inhibition.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1996年第1期73-74,共2页
Chinese Journal of Pharmacology and Toxicology
关键词
烫伤
心肌保护
山莨菪碱
大鼠
anisodamine
burn
lipid pero- xides
phospholipase A 2
