摘要
目的探讨小肠内滴注健脾通里中药对胃癌术后早期细胞因子白细胞介素-2(IL-2)、可溶性白介素-2受体(sIL-2R)和白细胞介素-12(IL-12)调控及其临床意义。方法60例将要手术的胃癌患者随机分为研究和对照两组。研究组(30例)术后第1天小肠内滴注健脾通里中药;对照组(30例)术后第1天小肠内滴注生理盐水;疗程均为7天。观察手术前后IL-2、sIL-2R和IL-12变化。结果与术前比较,两组IL-2、IL-12升高,sIL-2R降低,研究组差异有显著性(P<0·05);对照组上述指标虽有所改善,但差异无显著性(P>0·05);研究组与对照组比较,IL-2升高和sIL-2R降低,差异有显著性(P<0·05)。结论胃癌术后早期肠内滴注健脾通里中药能够提高机体免疫功能;这对防治术后早期严重并发症的发生,改善预后、提高临床生存率都具有重要意义。
Objective To explore the regulation and clinical significance of intestinal dripping of Jianpi Tongli （JPTL） Chinese herbs on levels of serum cytokines, such as interleukin-2 （IL-2）, soluble interleukin-2 receptor （slL-2R） and interleukin-12 （IL-12） in treating patients with gastric cancer （GC） at early post-operational stage. Methods Sixty patients with GC were randomly divided into two groups, i.e. the studied group （n = 30）, treated with JPTL Chinese herbs, and the control group （n = 30） treated with normal saline. The medication was started from the 1 st day after operation by intestinal dripping daily, 7 days as one course. Levels of IL-2, sIL-2R and IL-12 were observed before and after operation. Results Significant difference was seen on the 7th day post-operation between the studied and the control group, mainly in aspects of obvious increase of IL-2 and decrease of sIL-2R （ P 〈 0.05）, no significant difference in IL-12 was found （P 〉 0.05） though there was certain improvement. Compared with pre-operation of the same group, significant difference was found in the studied group in the increased IL-2 and IL-12 and decreased sIL-2R on the 7th day post-operation, while no significant difference in these indexes was found in the control group （P 〉0.05）, though certain improvement was shown. Conclusion Early intestinal dripping of JPTL Chinese herbs to post-operational patients with GC could improve their immune function, which was of important significance in early preventing the severe complications, improving the prognosis, and elevating the survival rate.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2005年第8期710-713,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家中医药管理局基金项目(No.00-01LP01)
安徽省教育厅自然科学基金项目(No.JL148)
