摘要
目的分析不同级别高血压与血浆硫化氢浓度的关系。方法采用分光光度法检测42例原发性高血压初诊患者及20例健康体检者血浆硫化氢的浓度,并且对硫化氢与血压的相关性进行分析。结果(1)高血压组硫化氢水平(37.08±10.36)μmol/L明显低于正常对照组(50.98±6.23μmol/L),P<0.001。(2)高血压1级组、2级组、3级组硫化氢的浓度分别为(47.73±3.87)μmol/L,(37.38±4.60)μmol/L,(26.87±7.56)μmol/L,并且差异显著(P<0.01)。(3)高血压组血浆硫化氢与收缩压和舒张压呈负相关(r=-0.7768,r=-0.7439,P<0.01)。结论原发性高血压初诊患者血浆硫化氢水平较低,且与血压水平呈负相关,提示内源性硫化氢减少参与了高血压的形成与发展。
Objective To study the relationship between the level of plasma hydrogen sulfide （ H2S） and different blood pressure grade in the patients with essential hypertension （ EH）. Methods Plasma H2 S levels were measured in 42 cases of EH and in 20 controls by spectrophotometry. Results （ 1 ） The plasma H2S levels were significantly lower in the group of EH （ 37.08 ± 10.36）μmol/L, than in the group of controls （50.98 ± 6.23 ）μmol/L, （P 〈 0. 001 ）. （2） The levels of plasma H2S in grade 1, grade 2 and grade 3 in EH were 47.73 ±3.87, 37.38±4.60 and 26.87 ±7.56 （μmol/L） respectively, and the difference among them was highly remarkable （ P 〈 0.01 ）. （ 3 ） Negative correlation was noted between the level of plama H2S and systolic pressure or di- astolic pressure （ r = - 0. 7768 or - 0. 7439, P 〈 0.01 ）. Conclusion The level of plasma H2S was lower and correlated nega- tively with blood pressure, which means the decrease of plasma H2S might be involved in the generation and development of EH.
出处
《临床军医杂志》
CAS
2005年第4期393-395,共3页
Clinical Journal of Medical Officers
关键词
原发性高血压
初诊
分级
硫化氢
essential hypertension
maiden diagnosis
grade
hydrogen sulfide
