摘要
兴奋缰核（Ｈｂ）的不同区域对血压可能具有不同的影响，本实验在乌拉坦麻醉的大鼠上进行，Ｌ─谷氨酸（Ｌ─Ｇｌｕ）经玻璃微电极被分别注入到内侧缰核（ＭＨｂ）和外侧缰核（ＬＨｂ）。结果可见，内侧缰核（ＭＨｂ）兴奋可明显提高血压和心率，血压由１３．８７±２．４１升高至１６．２１±４２ｋｐａ（Ｐ＜０．００１），心率由４３２．１８±４３．３１升高至４４８±３９．５５ｂ／ｍｉｎ（Ｐ＜０．００１），而外侧缰核（ＬＨｂ）兴奋引起不同的结果，血压由１４．８±２．０６降低到１３．０９±１．８２ｋＰａ（Ｐ＜０．００１），心率无明显改变，结果表明，兴奋缰核对心血管活动的影响具有部位特异性。
Excitation of different areas of habenula (Hb) seems to have different influences on blood pressure. The present experiments were performed on rats anaesthetized with urethane. L─Glutamic acid (L─Glu) was injected into medial (MHb) and lateral habenular nucleus (LHb) via glass pipettes. The results were that activation of the MHb increased blood pressure (from 13.87±2.14 to 16.21±2.42 kpa) (p<0.001)and heart rates (from 432.18±43.31 to 448±39.55b/min) (p<0.001), whereas stimulation of LHb decreased blood pressure (from 14.8±2.06 to 13.09±1.82 kpa) (p<0.001), and did not affect heart rates. It shows that the Hb has a regional specificity in regard to cardiovascular regulation.
出处
《神经科学》
SCIE
CAS
1995年第4期160-161,共2页
Chinese Journal of Neuroscience
关键词
缰核
血压
L谷氨酸
habenula
blood pressure
L─Glutamic acid
