摘要
目的:探讨地黄多糖(RGP-b)的作用机制. 方法:在RGP-b产生抑瘤作用的9 d过程中,观察它对S180荷瘤小鼠免疫功能的影响.结果:RGP-b 10或20 mg kg在d-9扭转细胞毒性T-淋巴细胞(CTL)活力的下降和部分改善IL-2分泌能力的衰落.对lyt-2+亚群及CTL活力的作用呈同步且始终使L3T4+:lyt-2+亚群间的比值低于对照组. 结论:增强lyt-2+CTL对肿瘤的杀伤能力是RGP-b免疫抑瘤的重要机制.
To study immuno-antitumor action mechanism of RGP-b. RGP-b (Rehmannia glutinosa polysaccaride b) is a new component isolated from the herb, had an everage molecular mass of 160 kDa and 5 kinds of monosac-charides as acid-splitting products. Its HPLC showed a main sharp peak at 162 kDa. METHODS: The kinetic effects of RGP-b onIL-2 secretion, cytotoxic T-lymphocyte (CTL) activities and L3T4+, lyt-2+ T-lymphocyte subset in mice bearing S180 were observed. RESULTS: RGP-b 10 or 20 mg kg-1 ip obviously attenuated the decrease of CTL cytotoxity caused by excessive tumor growth on d 9 after the administration, but only partly ameliorated the descent of IL-2. Its effect on CTL cytotoxity. RGP-b kept the ratio of L3T4+ to lyt-2+ subset lower than that of control.CONCLUSION: Improving the production of lyt-2+ CTL and its cytotoxity were an essential immuno-antitumor mechanisms of RGP-b.
出处
《中国药理学报》
CSCD
1995年第4期337-340,共4页
Acta Pharmacologica Sinica
关键词
地黄
多糖
肉瘤180
药理
T淋巴细胞
Rehmannia glutinosa
polysaccharides
sarcoma 180
interleukin-2
cytotoxic T - lymphocytes
T - lymphocyte subsets
CD_4-CD_8 ratio
