摘要
用单克隆抗体技术测定了16例病程在1.5年以上的IDDM患者和18例正常人外周血总T淋巴细胞及其亚群,显示两组间OKT_3、OKT_4、OKT_8、OKT_4/OKT_8差异均无显著性。提示病程超过1.5年的IDDM者的细胞免疫功能已趋于稳定。且16例IDDM患者的总T淋巴细胞及其亚群在胰岛移植前、后差异也没有显著性,认为目前国内应用的胡氏胰岛组织培养法有利于降低胰岛组织对人IDDM受体的免疫原性。
By means of monoclonal antibody OKT series it is possible to subclassify T lymphocytes. Thus making appraisement of the immunological function of the patients possible. Hereby we presented the result of observation among 16 cases of IDDM in comparison with 18 normal individuals. The result showed that there is no significant difference in OKT3, OKT4, OKTe, OKT, / OKT, of IDDM and normal individuals (63.99±3.34%, 36.70±3.86%, 27.78±4.18%, 1.318 ±0.24 and 64.5±3.13%, 36.05±3.18%, 24.90±3.07%, 1.46±0.22% respectively).
It suggested that cell immune function of patients with IDDM whose course beyond one and half years was steady.
Therefore, the levels of 16 IDDM's T lymphocytes before and after transplantation were not significantly changed. It suggested that Hu's pancreatic island tissue culture was favourable to reduce immunogenicity of pancreatic island tissue to human being IDDM receptor.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1989年第1期27-28,共2页
Chinese Journal of Endocrinology and Metabolism
关键词
胰岛素依赖型
糖尿病
T细胞
IDDM OKT series Monoclonal antibody Pancreatic island transplantation
