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胰岛素依赖型糖尿病免疫学研究进展 被引量：2

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摘要 十余年来在胰岛素依赖型糖尿病(IDDM)免疫学研究领域取得了很大进展,这些研究成果为IDDM病因的阐明、早期诊断及治疗奠定了基础。本文就有关IDDM免疫学近年来的研究进展予以综述。 一.自身免疫性胰岛炎: 早在本世纪初就发现死于糖尿病酮症的儿童胰岛内有单核细胞浸润现象,以后发现这种特异性的胰腺病理改变仅见于有酮症倾向的糖尿病患者。
作者 郝伟
机构地区 北京协和医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 1989年第3期165-168,共4页 Chinese Journal of Endocrinology and Metabolism
关键词 胰岛素依赖型 糖尿病 免疫学
分类号 R587.103 [医药卫生—内分泌]
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参考文献8

  • 1吴艺捷,赵立,姚莉莉,王煜非,董维平,张爱芳,王丽娟.老年糖尿病患者血清胰岛自身抗体检测的意义[J].上海医学,2003,26(1):10-13. 被引量：1
  • 2单忠艳,滕卫平,邸国勋.胰岛素细胞抗体—测定及与糖尿病的关系[J].中国医科大学学报,1992,21(4):268-270. 被引量：4
  • 3C. Betterle,F. Presotto,B. Pedini,L. Moro,R. S. Slack,F. Zanette,R. Zanchetta. Islet cell and insulin autoantibodies in organ-specific autoimmune patients. Their behaviour and predictive value for the development of Type 1 (insulin-dependent) diabetes mellitus. A 10-year follow-up study[J] 1987,Diabetologia(5):292～297
  • 4M. Uusitupa,Onni Siitonen,K. Py?r?l?,A. Aro,K. Hersio,I. Penttil?,E. Voutilainen. The relationship of cardiovascular risk factors to the prevalence of coronary heart disease in newly diagnosed Type 2 (non-insulin-dependent) diabetes[J] 1985,Diabetologia(9):653～659
  • 5P. Sai,M. Kremer,C. Maurel. Antibodies spontaneously bound to islet cells in diabetic C57BL/KsJ db/db mice[J] 1984,Diabetologia(1):139～142
  • 6A. Galluzzo,C. Giordano,G. Rubino,G. D. Bompiani. Immunoregulatory T-lymphocyte subset deficiency in newly diagnosed Type 1 (insulin-dependent) diabetes mellitus[J] 1984,Diabetologia(6):426～430
  • 7A. K. Foulis,J. A. Stewart. The pancreas in recent-onset Type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue[J] 1984,Diabetologia(6):456～461
  • 8T. Dyrberg,P. Poussier,F. Nakhooda,E. B. Marliss,?. Lernmark. Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB rat[J] 1984,Diabetologia(2):159～165

二级参考文献9

  • 1滕卫平，上海免疫学杂志，1983年，4卷，252页
  • 2Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 1997, 20: 1183-1197.
  • 3Borg H, Gottsater A, Landin-Olsson M, et al. High levels of antigen-specific islet antibodies predict future β-cell failure in patients with onset of diabetes in adult age. J Clin Endocrinol Metab,2001, 86:3032-3038.
  • 4Zimmet P, Turner R, McCarty D, et al. Crucial points at diagnosis. Type 2 diabetes or slow type 1 diabetes. Diabetes Care, 1999,22(Suppl 2) :B59-B64.
  • 5Hawa MI, Fava D, Medici F, et al. Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality. Diabetes Care, 2000, 23:228-233.
  • 6Pietropaolo M, Barinas-Mitchell E, Pietropaolo SL, et al. Evidence of islet cell autoimmunity in elderly patients with Type 2 diabetes. Diabetes, 2000, 49:32-38.
  • 7Molbak AG, Christau B, Marner B, et al. Incidence of insulin-de-pendent diabete mellitus in age groups over 30 years in Denmark.Diabetes Med, 1994, 11:650-655.
  • 8Shimada A, Imazu Y, Morinaga S, et al. T-cell insulitis found in anti-GAD65 + diabetes with residual β-cell function. Diabetes Care, 1999, 22:615-617.
  • 9Pozzilli P, Di Mario U. Autoimmune diabetes not requiring insulin at diagnosis (Latent autoimmune diabetes of the adult): definition,characterization, and potential prevention. Diabetes Care, 2001,24:1460-1467.

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中华内分泌代谢杂志
1989年 第3期

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