摘要
报道了３９个新的１－｛２－［（取代苯基）甲氧基］－２－（取代苯基）乙基｝－１Ｈ－三唑和苯并三唑类化合物的合成与体外抑菌试验，结果表明，化合物６，１３的抗真菌活性为益康唑的４～１０倍，化合物１０，１２，１４，１５，２０，２２，２３，２８．３０和３１等对大部分真菌活性也优于或相当于益康唑及克霉唑，化合物２３和３１抗裴氏着色菌活性为益康唑、克霉唑的３０倍以上，化合物２２抗白念珠菌活性为益康唑的８倍，克霉唑的４倍。
Thirty-nine1-{2-[(2,4-dichlorophenyl
)methoxy]-2-(substituted-phenyl)ethyl}-1H-triazoles and benztriazoles
were svnthesized and all title compounds are reported for the first
time.Results of preliminary biological tests showed that the most
active compounds 6 and 13 are 4～10times more active than the lead
compound econazole.The antifungal activities of compounds 10
,12,14,15,20,22,23,28,30 and 31 are better than or comparable to the
activities of econazole andclotrimazole against most fungi.Compounds
23 and 31 are 30 times more active than econazole andclotrimazole
against Fonseaea pedrosoi.Compound 22 is 4 and 8 times more active
than clotrimazole andeconazole, respectively,against Candide
albicans.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第3期191-204,共14页
Acta Pharmaceutica Sinica
基金
总后卫生科研基金
