摘要
目的 对内镜活检胃正常及良、恶性组织中胃泌素样细胞进行了观察和对照研究,并探讨了其临床意义。 方法 消化性溃疡47例,其中胃溃疡28例,十二指肠溃疡19例,胃癌25例及其癌旁非癌粘膜组织经内镜活检获取,胃泌素样细胞的观察采用免疫组化方法。 结果 ①十二指肠溃疡患者G细胞计数为120.7±18.4/mm^2,高于正常(P<0.01),胃溃疡G细胞计数为69.4±6.2/mm^2,与正常相似,(P>0.05)。②癌旁非癌粘膜G细胞计数增高;③28％(7/25)胃癌组织中存在胃泌素样细胞。 结论 ①十二指肠溃疡的发生可能与G细胞增多有关。②胃癌组织中存在胃泌素样细胞的分化。③癌旁G细胞增生可能是胃癌的一种高危征象。
AIM Gastrin - immunoreactive cells (G cells) were observed in benign and malignent tissues of the stomach obtained by endoscopic biospy and its clinical significance was investigated.METHODS Biospy tissues of 47 peptic ulcer(28 gastric ulcer, 19 duodenal ulcer) and 25 gastric carcinoma and their adjacent noncancerous mu-cosa were obtained by endoscopy. G cells were observed in these tissues by immunohistochemistry.RESULTS ① cell count in duodenl ulcer(DU) was 120.7±18.4/mm2, higher than that in normal dividuals(P<0.01). In gastric ulcer (GU), it was 69.4±6.2/mm2, similar to that in normal dividuals(P>0.05). ②?G cell proliferation in adjacent noncancerous mucosa in gastric carcinoma was observed. (?)/cells were found in 28%(7/25) gastric carcinoma tissues.CONCLUSION ① cells hyperplasia may be related to the occurence of DU. ②ifferentiation of G cells exists ih gastric carcinomas.③roliferation of G cells in adjacent noncancerous mucosa of gastric carcinoma may be considered as a high risk marker.
关键词
消化性溃疡
胃泌素样细胞
胃肿瘤
peptic ulcer gastric carcinoma gastrin - immunoreactive cell
