摘要
实验着重观察了川芎嗪与扩血管药物或强心剂配伍应用对慢性缺氧大鼠血气、血流动力学的影响和对肺循环作用的选择性．结果显示：川芎嗪与与强心剂参麦注射液和多巴酚丁胺合用，在降肺动脉压和肺循环阻力方面与川芎嗪单用或川芎嗪与扩血管药物心痛定、ＤＤＰＨ合用效果相似，但对心脏及体循环的副作用则较小；特别是川芎嗪与参麦注射液合用对肺循环的作用有较好选择性．表明川芎嗪与参麦注射液的合用在治疗肺动脉高压方面有一定应用价值．
To evaluate the clinical effect of ligustrazine and its combination use with other drugs for treatment of pulmonary hypertension in COPD patients, we examined the effect of ligustrazine and its combination use with other drugs on blood gas, hemodynamics and their selective action on pulmonary circulation. The results showed that the ligustrazine combined with Nifedipine or DDPH could decreased the mean pulmonary artery pressure and total pulmonary vascular resistance more than ligustrazine alone. But the side-effect of the combined uses on systemic circulation and heart function were much less. when ligustrazine was used in combination with Shenmai injection or dobutamine, less side-effects on systemic circulation and heart function and better selectivity on pulmonary circulation were observed,especially when used in combination with shenmai Injection. The results demonstrated that the ligustrazine used with Shenmai Injection may be of some value for treatment of pulmonary hypertension in COPD patients.
出处
《同济医科大学学报》
CSCD
北大核心
1995年第5期358-361,共4页
Acta Universitatis Medicinae Tongji
基金
国家"八.五"攻关项目
关键词
川芎嗪
缺氧症
肺动脉高压
ligustrazine
hypoxia
hypertension
pulmonary
drug combination
