摘要
按照粘液组化染色结果，９６例人类胃粘膜上皮异型增生标本，被区分为分泌中性粘液的异型增生（ＮＭ－ｄｙｓ）５７例和分泌非中性粘液的异型增生（Ｎ－ＮＭ－ｄｙｓ）３９例两类。中、重度异型增生的检出率，在ＮＭ－ｄｙｓ中为３６．８％（２１／５７），在Ｎ－ＮＭ－ｄｙｓ中为７６．９％（３０／３９），两者比较差异有显著性（Ｐ＜０．０５）；免疫组化染色结果显示，Ｐ２１、Ｐ５３蛋白表达阳性率在Ｎ－ＮＭ－ｄｙｓ中（５３．３％、４８．７％）亦显著地高于ＮＭ－ｄｙｓ（２４．６％、２２．８％）（Ｐ＜０．０５）。结果表明：分泌非中性粘液的异型增生组织细胞基因表达异常，细胞分化功能障碍，带有更多与胃癌相同的生物学性状，应视为重要的胃癌前病变。我们建议将粘液组化染色列为判断胃粘膜上皮异型增生是否容易恶变的一个初筛指标。
Ninety six specimens of dysplasia from the biopsy specimens of gastric mucosa were divided into two kinds i. e. dysplasia secreting neurtal mucin (NM-dys ,57 cases)and dysplasia secreting non-neutral mucins (N-NM-dys, 39 cases)according to the results of mucin histochemical stainings. The incidence of histologically moderate and severe dysplasia is significantly higher in N-NM-dys (76. 9%) than in NM-dys (36. 8%) (P<0. 05). The positive rates of p21 protein and p53 protein by ABC immunohistochemistry in N-NM-dys (53. 3 % , 48. 7%) were also statistically higher than those in NM-dys (24. 6 %, 22. 8%) (P<0. 05). These results revealed that N-NM-dys may more easily progress to gastric cancer than NM-dys,and N-NM-dys should be considered to be the high-risk precancerous lesion of gastric cancer.We suggest that histochemical mucin stainings should be performed for all histologically diagnosed dysplasia specimens from the biopsied gastric mucosa so as to detect high-risker of gastric cancer.
出处
《内镜》
1995年第2期69-71,共3页
