摘要
目的：研究突变型ｐ５３和ｃ－ｎｅｕ癌基因产物在胃癌中的表达。方法：用免疫组化方法检测４７例胃癌组织中突变型ｐ５３蛋白和ｃ－ｎｅｕ癌基因产物的表达。结果：４７例胃癌组织中ｐ５３的阳性率为６１．７％，可分为胞浆型、核型以及全细胞型。胞浆型与胃癌高分化有关，核型与胃癌低分化有关（Ｐ＜０．０１）。２例早期胃癌中，１例呈胞浆ｐ５３阳性，另１例呈ｐ５３阴性。ｃ－ｎｅｕ阳性率为９１．５％，与胃癌组织学分型无关，多分布在胃癌细胞的胞浆及胞膜，少数在核膜上。突变型ｐ５３和ｃ－ｎｅｕ共同表达率为４８．９％。结论：突变型ｐ５３和ｃ－ｎｅｕ癌基因在胃癌发生、发展过程中具有协同作用。
Purpose To study the expression of mutant p53 and c neu in gastric carcinoma. Methods The expression of mutant p53 and c neu in 47 gastric carcinoma tissues was studied by immunohistochemical technique. Results The positivity rate of mutant p53 in tissues of 47 cases of gastric carcinomas was 61 7%. p53 expression in tumor cells was divided into karyo type, cytoplasmic type and cell type. The cytoplasmic type correlated with the well differentiation and the karyo type with the poor differentiation in gastric carcinoma ( P <0 01). In two early gastric carcinomas, one expressed mutant p53 while the other was negative. c neu expression in gastric carcinoma tissues was 91 5%. There was not any association between c neu staining and histological types of gastric carcinoma. c neu oncoprotein was mainly located in the cytoplasm and the membrane of gastric cancer cells, occasionally on the nuclear membrane. Coexpression of mutant p53 and c neu in gastric carcinoma tissues was 48 9%. Conclusions There is synergistic action between mutant p53 and c neu in the process of gastric carcinoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
1997年第1期32-32,共1页
Chinese Journal of Clinical and Experimental Pathology
