摘要
为观察中性粘多糖（ＮＭ）对缺血再灌流脑组织损伤的作用，我们应用沙土鼠制成的全脑缺血模型，测定缺血组织中的三磷酸腺苷（ＡＴＰ）、超氧化物歧化酶（ＳＯＤ）及脂质过氢化物（ＬＰＯ）。结果显示，提前服用ＮＭ，在缺血时可使脑组织ＡＴＰ含量恢复到正常水平，也可提高再灌流时脑组织ＡＴＰ水平，且后者随着ＳＯＤ活力升高，ＬＰＯ的含量降低，其含量有所恢复。提示ＮＭ对缺血再灌流的脑损害有保护作用。其机制是通过促使ＡＴＰ的重新合成和清除自由基，从而改善脑能量代谢。
AbstractTo investigate the protective function of neutral mucopolysaccharide(NM)on brain damagefollowing cerebral ischemia and reperfusion,we measured brain adenos,ine triphco,phate(ATP),su-peroxide dismutase(SOD),lipid peroxidation(LPO)in global cerebal ischemic medels of gerbil.The results showed that it pretreat with NM in cerebral ischemia,brain ATP level was restored tonormal level.After reperfusion,it was also eleveted.Brain SOD increased and LPO decreasedrapidly,ATP was also eleveted.The study suggests that NM plays a role in protecting cellular dam-age of ischemia and reperfusion. The mechanism is that it can promote resynthesis of ATP andscavenge free radicals,which improves energy metabolism.
出处
《临床神经病学杂志》
CAS
1995年第2期95-97,共3页
Journal of Clinical Neurology
基金
上海科委自然科学基金
