摘要
采用生物活性法检测了80例各型肝炎患者血浆血小板衍化生长因子(PDGF)活性。结果:正常人血浆PDGF活性为35±10u/ml,而各型肝炎患者血浆PDGF活性均明显高于正常人对照组,且与患者血清Ⅲ型前胶原含量密切相关(r=0.751)。本文认为,PDGF活性测定不仅有助于肝纤维化发病机制的研究,而且可用于判定病情,指导治疗。
Platelet-derived growth factor (PDGF) activity in plasma of patients with acute hepatitis (AH), chronic persistent hepatitis (CPH), chronic active hepatitis (CAH) and posthepatitis cirrhosis (HC) have been detected by bioactivity assay. The results indicated that the activity of PDGF increased in plasma from patients with AH(74±27U/ml,p<0. 05), CPH(51±18U/ml, p<0.05),CAH(142±45U/ml, p<0.01) and HC (187±63U/ ml,p<0.01) as compared with nomal subjects (35±10U/ml).The enhancement of PDGF activity in viral hepatitis was closely related to the level of patient's serum precollegen type Ⅲ(r=0.751).It is suggested that detecting PDGF activity will allow us to define the pathogenesis of hepatic fibrosis and help us to evaluate the severity of the illness and direct the treatment.
出处
《临床肝胆病杂志》
CAS
1995年第3期128-130,共3页
Journal of Clinical Hepatology
