摘要
采用细胞生物活性法检测了 80例乙型肝炎患者白细胞介素 6 (IL- 6 )和血小板源生长因子 (PDGF)水平。结果表明 :急性肝炎、慢性肝炎和肝硬化患者的 IL- 6和 PDGF的活性明显高于正常对照组 ,且与患者的血清 型前胶原肽 (PC )含量密切相关 (r=0 .6 1,r=0 .75 )。提示 IL- 6和 PDGF活性的变化可能与肝纤维化的发病机理有关 ,在慢性肝炎向肝硬化转变的过程中起促进作用。
Objective: To investigate the relationship of levels of seruminterleukin 6 (IL 6) and platelet derived growth factor (PDGF) to hepatic fibrosis in hepatitis B. Methods: The levels of serum IL 6 , PDGF and precollagen type Ⅲ were determined in 80 cases of hepatitis B cellular bioactivity assay and RIA, and compared with 20 normal controls. Results: The levels of IL 6 and PDGF were higher significantly in patients with acute hepatitis, chronic hepatitis and posthepatitic cirrhosis as compared with the normal controls and related closely to the level of precollagen type Ⅲ (r=0.6, r=0.75). Conclusion: It is suggested that the changes of IL 6 and PDGF may be related to the pathogenesis of hepatic fibrosis and play an important role in the process from chronic hepatitis to cirrhosis.
出处
《江西医学院学报》
2000年第2期69-71,共3页
Acta Academiae Medicinae Jiangxi
