摘要
目的观察3种不同免疫抑制剂治疗狼疮性脑病的疗效和不良反应。方法44例狼疮性脑病患者随机分为3组,分别应用甲基泼尼松龙(A组)、环磷酰胺(B组)、异环磷酰胺(C组)冲击治疗;定期检测血沉、血清补体的动态变化,评估其疗效和不良反应。结果(1)3组治疗1个月和3个月血沉均较治疗前明显下降(均P<0.01),B组、C组较A组下降更明显;血清补体C3治疗前后变化不明显(均P>0.05)。(2)治疗3个月后C组显效率为62.5%,B组显效率为42.8%,明显高于A组的21.4%(均P<0.01),B组和C组不良反应少且轻微。结论大剂量异环磷酰胺、环磷酰胺冲击治疗狼疮性脑病疗效优于单纯糖皮质激素。
Objective To investigate the efficacy and safety of three kinds of immunosuppressant on systemic Iupus erythematosus encephalopathy. Methods 44 cases with systemic lupus erythematosus encephalopathy were randomly assigned to receive high dose of Methyllprednisolone, Cytoxan （CTX） or Ifosfamide （IFO）. The levels of ESR and serum C3 were detected at different time after treatments： The effect and safety of these treatments were evaluated. Results （ 1 ） After treatment, the levels of ESR decreased significantly （ P 〈 0.01 ） in all the patients. But there was no significant difference of serum C3 （P〉0.05 ）. More decrease of ESR was found in CTX group and IFO group than in Methyllprednisolonc group （all P 〈 0.05 ）. （2） Better clinic results were found in IFO group （62.5% of the cases with significant improvement） and CTX group （42.8% of the cases with significant improvement） than in Methyllprednisolone group （only 21.4% of the cases with significant improvement） （all P 〈 0.01 ）. Moreover, fewer side effects were observed in IFO and CTX group. Conclusion High dose use of CTX or IFO is better than Methyllprednisolone in treating systemic lupus erythematosus eneephalopathy.
出处
《临床神经病学杂志》
CAS
北大核心
2005年第4期276-278,共3页
Journal of Clinical Neurology
