摘要
目的:探讨血浆同型半胱氨酸(Hcy)、叶酸(FA)、VitB12与血管性痴呆(VaD)的相关性。方法:检测VaD患者86例(VaD组),非VaD患者87例(非VaD组),健康体检正常者90例(正常组)血浆Hcy、FA、VitB12浓度。并对3组受检者进行简易智能状态量表(MMSE)评定。结果:VaD组患者Hcy浓度显著高于非VaD组及正常组(P<0.01)。FA、VitB12浓度与Hcy浓度负相关。血浆Hcy、FA、VitB12水平与VaD、MMSE得分显著相关(P<0.01)。结论:VaD高危人群应定期检测Hcy浓度,推荐服用VitB12和FA可预防VaD的发生。
Objective： To investigate the relationship between plasma homocysteine（Hcy）,folate,vitamin B12and vascular dementia（VaD）.Methods： The plasma levels of Hcy,folate,vitamin B12 and MMSE were measured in 86 VaD patients,87 non-VaD cerebral vascular disease patients,and 90 age-matched normal controls of Affiliated Hospital,North China Coal Medical University.Results： The plasma Hcy levels were significantly increased in the VaD group than non-VaD cerebral vascular disease group and normal controls（P〈0.01）.The Hcy level was negatively related with folate and VitB12 levels.They all significantly correlated with VaD and the MMSE score（P〈0.01）.Conclusion： The levels of Hcy,folate and vitamin B12 were significantly correlated with VaD.
出处
《中国康复》
2012年第2期95-96,共2页
Chinese Journal of Rehabilitation
