摘要
ICR小鼠受致死量射线照射以后,接受有机锗治疗14天.剂量为500mg/kg的小鼠30天活存率比对照组提高37.5％;当Ce—132剂量为500mg/kg和1000mg/kg时,其内源性脾结节的数量明显地高于对照组。实验结果表明,Ce—132具有一定的治疗急性骨髓型放射病的作用和刺激内源性造血干细胞的增殖与分化作用。
ICR mice, irradiated lethally by 60Co r-ray, were administered orally and daily with varying doses of organic germanium for 14 days. The 30-day survival rate of those mice administered with a dose of 500mg/kg was increased by 37.5% as compared with the control group ( P<0.0l) . Significant stimulating effects of Ge-132 on internal colony forming units in spleen (CFU-S) of mice were also found. The results showed that organic germanium compound has certain protective effect on lethally irradiated mice and stimulating effects on the proliferation and differentiation of hematopoietic stem cells.
出处
《第一军医大学学报》
CSCD
1989年第3期211-213,共3页
Journal of First Military Medical University
关键词
有机锗
骨髓型
放射病
造血干细胞
Organic germanium compound
bone marrow acute radiation disease
hematopoietic stem cells
CFU-S
