摘要
本文用荧光探剂ANS,NPN和DPH研究联苯双酯对人红细胞膜不同层次流动性的影响。结果表明:该药可降低膜表层流动性(ANS为探剂),增加膜中层(NPN为探剂)和深层(DPH为探剂)的流动性。此外,还发现该药对由丙二醛诱发的溶血有保护作用。综合以上结果,作者对联苯双酯的药理作用进行了扼要的讨论。
This paper deals with the effects of DDB on human RBC membrane fluidity as reflected by changes in the phase transition temperature and microviscosity monitored by ANS, NPN and DPH The results showed that DDB decreased the fluidity of the shallow layer (ANS as probe), but increased the fluidity of the middle layer (NPN as probe) and deeper layer (DPH as probe). In addition the. drug was found to inhibit the hemolysis indnced by MDA.
出处
《药学学报》
CAS
CSCD
北大核心
1989年第1期1-4,共4页
Acta Pharmaceutica Sinica
关键词
联苯双酯
膜
流动性
红细胞
Biphenyl dimethyl dicarboxylate(DDB)
Membrane fluidity
Phase transition temperature
