摘要
应用免疫组织化学技术检测１１４例胃癌组织的雌激素受体（ＥＲ）。结果：ＥＲ阳性２７例（２３．７％）；主要见于ＴＮＭⅡ、Ⅳ期，ＢｏｒｒｍａｎｎⅣ型及Ｌａｕｒｅｎ弥漫型胃癌；胃癌伴淋巴结和／或器官转移者ＥＲ阳性率明显增高，其差异有显著性（Ｐ＜０．０５）；患者５年生存率与ＥＲ阳性率呈负相关（Ｐ＜０．０５）。提示：胃癌可能是雌激素依赖性肿瘤，ＥＲ可作为胃癌的生物学标记。
Paraffin-embedded materials from 114 patients with primary gastric cancer were examined for the expression of Estrogen Receptor (ER), ER positive cases were characterized grossly as Borrmann Ⅳ、TNM Ⅲ、Ⅳ and microscopically as diffuse type with scirrhows growth pattern. A significant positive correlation was found between ER status and lymph node status. The five-year surrival rate of patients with positive ER was Lower than thoses with negative ones. These results indicate that the sex hormonal factors are involved in gastric cancer. and ER detected by ABC method may be used as biomarkers for tumor differentiation and have Prognostic values in gastric cancer.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1995年第6期363-364,F004,T001,共4页
Cancer Research on Prevention and Treatment
关键词
胃肿瘤
雌激素受体
受体
gastric cancer
estrogen receptor
prognose
