摘要
本文应用石蜡切片免疫组化ＰＡＰ法，回顾性观察了６１例直肠中分化管状腺癌组织ＥＲ、ＰＲ表达情况。ＥＲ（＋）／ＰＲ（＋）为４２．６％；ＥＲ（－）／ＰＲ（－）为５７．４％。ＥＲ／ＰＲ的存在表明该癌组织具有了依赖性激素的特性。ＥＲ（＋）／ＰＲ（＋）者的中位生存期为４．５年，一、三、五年生存率为８８．５％、５３．９％、３８．５％，均高于ＥＲ（－）／ＰＲ（－）者的生存率。 ＥＲ（－）／ＰＲ（－）者的中位生存期为２．４年，一、三、五年生存率为６５．７％、４２．８％、２８．６％。表达阳性与阴性两者的生存期有明显差异（Ｐ＜０．０１）。检测ＥＲ／ＰＲ受体亦可做为判定预后的指标之一。本实验证实ＥＲ、ＰＲ表达与年龄、性别以及ＬＮＭ之间无明显差异（Ｐ＞０．０５）。
Expression of ER and PR in 61 cases with rectal middle differentiated adenocarcinoma were abserved by immunohistochemistry PAP method on paraffin section. The positive or negative rate of ER/PR were 42. 6% (26/61) or 57. 4% (35/61). The existance of ER/PR indicated that rectal cancernoma tissues possessedthe characteristic of depending upon sexhormone. The middle survival time of ER(+)/PR(+) or ER(-)/PR(-) was 4. 5-year time or 2. 5-year time. The 1,3, 5year survival rate of ER(+)/PR (+)(88. 5 %, 53. 9%, 38. 5%) were significantlyhigher than that of ER (-)/PR (-) (67. 5%, 42. 8%, 28. 6% ) (P<0. 01). It isconcluded that the expression ER/PR for rectal cancer patients may be consideredas one of the indicators in the prognosis but in age, sex and LNM.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1996年第1期30-31,共2页
Cancer Research on Prevention and Treatment
关键词
直肠肿瘤
ER
PE
受体
预后
病理学
Estrogen receptor (ER)
Progesterone receptor (PR)
Rectal cancer
Survival
