摘要
测定３２例老年原发性高血压患者、９例健康老年人及１０例健康青年人的尿液血栓素Ｂ２（ＴｘＢ２）、尿６－酮－前列腺素Ｆ１α（６－ｋ－ＰＧＦ１α）和血浆内皮素（ＥＴ－１）的浓度。结果表明，健康老年人较健康青年人尿中ＴｘＢ２有升高（ｔ＝４．０７，Ｐ＜０．００１），６－ｋ－ＰＧＦ１α降低（ｔ＝１２．２２，Ｐ＜０．００１），血ＥＴ－１差异无显著性（ｔ＝１．０３７，Ｐ＞０．０５）；而老年原发性高血压组较老年健康组尿液ＴｘＢ２和血浆ＥＴ－１升高，尿液６－ｋ－ＰＧＦ１α则降低，且随病情加重其间差异愈明显。这说明前列腺素和内皮素在高血压的发生、发展中均起重要调节作用。以尿液ＴｘＢ２、６－ｋ－ＰＧＦ１α及血浆ＥＴ－１值观察老年人原发性高血压的病情变化具有一定临床价值。
Abstract The concentration of urinary thromboxane B2(TxB2) 6-keto-prostaglandin F1α(6-keto-PGF1α) and plasma endothelin(ET-1) were measured in 32 aged patients with essential hypertension(EH),9 healthy old men and 10 healthy young men.The result showed that the healthy old men have higher level of urinary TxB2(P<0.001),lower urinary 6-keto-PGF1α(P<0.001),and no change of plasma ET-1(P>0.05) than the healthy young men.It is also shown that aged patients with EH have higher level urinary TxB2,plasma ET-1 and lower urinary 6-keto-PGF1α level than those healthy controls.It is found that the elevated level of urinary TxB2 and plasma ET-1 level may play a role in the development of EH and measurement of urinary TxB2 and 6-keto-PGF1α and plasma ET-1 may be of help in following the clinical course of EH in the elderly.
出处
《中华老年医学杂志》
CSCD
北大核心
1995年第4期211-213,共3页
Chinese Journal of Geriatrics
