摘要
用放射免疫法测定了110例正常妊娠妇女、23例正常非孕妇女外周血,20例正常阴道分娩妇女外周血和脐血,12例剖宫产孕妇胎盘、胎膜、蜕膜、子宫肌层组织及外周血中内皮素-1(ET-1)的含量。结果:与非孕期比较,正常妊娠期血浆ET-1明显下降,以孕中期最为显著;临产后血浆ET-1显著升高,与非孕期相比无显著差异。妊娠后至临产前及非孕期妇女血浆ET-1与平均动脉压均呈正相关。脐血ET-1为外周血的3.7和6.5倍,脐静脉血ET-1显著高于脐动脉。胎膜、胎盘、蜕膜及子宫肌层中ET-1分別为外周血的38、26、19、11倍。结论:ET-1可能在血压的生理调节、分娩发动和分娩过程中发挥重要作用。
We measured Plasma endothelin 1 (ET-1) concentrations in 110 normal pregnant women (NPW) and 23 normal non pregnant women (NNPW), that of maternal venous (MV), umbilical artery (UA) and umbilical vein (UV) in 20 normal parturient women at term (vaginal), and the tissue ET-1 concentrations of the placenta, fetal membrane, decidua and myometrium in 12 normotensive women at term (caesarean section) by radioimmunoassay. Results: compared with NNPW, plasma ET-1 levels were significantly decreased in NPW, and the lowest levels was in the second trimester. The plasma ET-1 levels were significantly increased in the labour, and were similar to that in NNPW. There were significant positive correlations between plasma ET-1 levels and mean arterial pressure in NNPW and NPW during the first, second and third trimester. UA and UV (ET -1) were 3.7 and 6.5 times of MV (ET 1), the UV (ET 1) was higher than UA (EF-1) significantly. The ET-1 concentrations of fetal membrane, placenta, decidua and myometrium were 38, 26, 19 and 11 times of MV (ET 1). Conclusions: ET 1 may play an important role in the initiation and process of labour and the regulation of blood pressure.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1993年第6期440-443,共4页
Medical Journal of Chinese People's Liberation Army
关键词
内皮素
妊娠
血压
分娩
Endothelin
Pregnancy
Blood pressure
Labour
