摘要
目的:本研究旨在观察空腹血清瘦素(FL)和胰岛素(FI)在高血压合并高尿酸血症患者的表达以及与无高尿酸血症的高血压患者和正常对照者的差异。方法:高血压合并高尿酸血症患者组163例,不伴高尿酸血症的高血压患者组63例,正常对照组28例。停止抗高血压药物2周及禁止高嘌呤饮食48小时后取空腹静脉血,检测血尿酸、血脂等。放免法检测FL和FI。结果:在高血压合并高尿酸血症组,FL、FI和HOMA指数(HOMA-IR)较不伴高尿酸血症的高血压组和正常对照组显著增高(P<0.01或P<0.05)。在不伴高尿酸血症的高血压组,仅FL以及HOMAIR较正常对照组增高(P均<0.05),而FI在两组间差异无显著。在控制了性别和年龄之后,在高血压合并高尿酸血症组,FL与血尿酸、体重指数、FI、HOMAIR、收缩压、腰围和心率成正相关(P<0.01)。HOMAIR与血尿酸、收缩压、舒张压和臀围成正相关(P<0.01或P<0.05),FI与血尿酸、收缩压和舒张压成正相关(P<0.01或P<0.05)。在高血压合并高尿酸血症组中作多元线形回归分析表明:血尿酸、体重指数、高密度脂蛋白胆固醇、HOMAIR、性别和心率进入以FL为因变量的回归方程。结论:高血压合并高尿酸血症组血中FL、FI和HOMAIR较不伴高尿酸血症的高血压患者组和对照组显著增高,表明高血压合并高尿酸血症患者中可能同时存在着异常的FL和FI以及胰岛素抵抗。
Objective:To investigate whether there are abnormal fasting serum leptin(FL),insulin(FI)and insulin resistance in patients with hypertension and hyperuricemia,and the resutts were compared with those in hypertensive patients without hyperuricemia and in the normal controls. Methods:The study included 163 patients with both hypertension and hyperuricemia,63 hypertensive patients without hyperuricemia and 28 normal controls. Results:The level of FL,FI,homeostasis model assessment-insulin resistance (HOMA-IR) index were higher in patients with both hypertension and hyperuricemia than those of hypertensive patients without hyperuricemia and those of the controls(p<0.01or p<0.05).After adjusted for sex and age,FL was significantly correlated with FI,HOMA-IR,serum uric acid,body mass index,heart rate,systolic blood pressure and waist circumference.HOMA-IR was significantly correlated with serum uric acid,systolic blood pressure,diastolic blood pressure and hip circumferance.In patients with both hypertension and hyperuricemia group,multivariance regression analyses showed HOMA-IR,serum uric acid,body mass index,sex,heart rate and high density lipoprotein entered the formula when FL was the dependent variable. Conclusion:The levels of FL,FI and HOMA-IR were higher in patients with hypertension and hyperuricemia than those of hypertensive patients without hyperuricemia and of the normal controls,suggesting that they may be closely associated with hyperuricemia and hypertension.
出处
《中国循环杂志》
CSCD
北大核心
2005年第3期190-193,共4页
Chinese Circulation Journal
