摘要
胃粘液－碳酸氢盐屏障是胃粘膜自身保护作用的重要机制之一。小柴胡汤及香砂六君子汤十二指肠给药１０ｇ／ｋｇ，可显著增加大鼠胃壁结合阿利新蓝量，显示促进胃粘液分泌作用。利用大鼠在体胃灌流装置，在奥美拉唑抑制大鼠胃酸分泌后，根据灌流液ｐＨ变化测定ＨＣＯ３分泌。胃内酸化（ｐＨ４．０）及静脉注射ＰＧＥ２ ６００μｇ／ｋｇ均能促进ＨＣＯ３分泌。小柴胡汤及香砂六君子汤水煎液胃内注射或十二指肠注射１０ｇ／ｋｇ，均未显示有促进ＨＣＯ３分泌作用。离休草蛙胃粘膜实验也未观察到二方有促进ＨＣＯ３分泌作用。
Mucus-bicarbonate' barrier is one of the mest impertant defence factors in gastric mucosa. The mucussecretion was measured by combination of Alcian Blue with mucus. XCHT and XSLJT 10g/kg i. d could sig-nificantly increase the amount of Alcian Blue. It suggests that XCHT and XSLJT could stimulate the secretionof gastric mucus. Using the perfusion device of stomach in rats. the secretion of HCO3 was measured throughthe changes of pH of gastric lumen in the absence of acid secretion induced by pretreatment with Omeprazole80-90mg/kg. i. d. The output of HCO3 could be significantly enhanced by HCI(gastric lumen pH4. 0)andPGE2 (600mg/kg.i. v). XCHT and XSLJT with dose of 10g/kg either i. d or i.g didn't show any effect onit. The two ptesctiptions had no effect on the secretion of HCO3 in isolated amphibian mucosa also.
出处
《中药药理与临床》
CAS
CSCD
1994年第6期3-6,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家中医药管理局科研基金
