摘要
在回流条件下,以乙醇为溶剂,4吡啶甲酰肼分别与4硝基苯甲醛、4氯苯甲醛、2氯苯甲醛、2,4二氯苯甲醛、3硝基苯甲醛、4甲氧基苯甲醛、呋喃甲醛和苯乙酮反应得到相应的中间体酰腙,再与乙酸酐环合,以良好的收率合成出含吡啶环的1,3,4唑啉类化合物.通过元素分析、IR,1HNMR和MS对其结构的表征,探讨了此类化合物的质谱裂解规律.
Condensation of 4-nicotinic hydrazine with 4-nitrobenzaldehyde,4-chlorobenzaldehyde,2-chlorobenzaldehyde,2,4-dichlorobenzaldehyde,3-nitrobenzaldehyde,4-methoxybenzaldehyde,furaldehyde and acetylbenzene produced corresponding hydrazones.Cyclization of intermediates with acetic anhydide gave the title compounds in good yield.Structures products were confirmed by elementary analyses,IR,~1HNMR,and MS spectroscopy,and fragmentation mechanism of MS spectra was discussed as well.
出处
《河北师范大学学报（自然科学版）》
CAS
北大核心
2005年第4期380-383,共4页
Journal of Hebei Normal University：Natural Science
基金
湖北省教育厅科学技术研究资助项目(2004D001)
关键词
1
3
4-噁唑啉
合成
结构表征
1,3,4-oxadiazoline
synthesis
structural characterization
