摘要
目的:评价双膦酸盐类药物在多发性骨髓瘤骨病治疗中的研究进展和临床应用情况。方法:查阅近期国内外相关文献,进行评价和分析。结果:在多发性骨髓瘤治疗中,双膦酸盐类药物在预防病理性脊柱骨折、高钙血症和缓解骨痛方面疗效显著,在预防非脊柱骨折、高钙血症和总生存率等方面无显著差异,不良反应轻微,常为恶心、呕吐、腹泻和便秘。结论:随着双膦酸盐类药物的开发进展,其药物强度越来越高,疗效更持久,不良反应更低,给多发性骨髓瘤骨病的治疗带来新的希望。
OBJECTIVE: To evaluate research progress and clinical application of bisphosphonates for the treatment of multiple myeloma(MM).METHODS: To review recent literatures at home and abroad for an analysis. RESULTS: Bisphosphonates had obvious curative effect on prevention of pathological spinal fracture, hypercalcinemia and relieving ostalgia, but no obvious difference in prevention of non-spinal fracture, hypercalcinemia and total survival rate. There were some slight adverse reactions, such as: nausea, vomiting, diarrhea and constipation. CONCLUSION: With the development of bisphosphonates, drug intensity has become more and more high, curative effect has lasted longer with less adverse reactions, so this kind of drug will have bright prospect for the treatment of MM.
出处
《中国医院用药评价与分析》
2005年第3期138-141,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
