期刊文献+

伊班膦酸钠配合放疗治疗恶性肿瘤骨转移疗效观察 被引量:1

暂未订购
导出
摘要 目的观察伊班膦酸钠配合放疗治疗恶性肿瘤骨转移疗效。方法治疗组42例恶性肿瘤骨转移患者每21天应用伊班膦酸钠4mg静脉点滴,同时配合放疗;对照组40例单纯应用放疗。结果治疗组骨痛缓解率88.10%,3d疼痛缓解率33.33%,对照组骨痛缓解率82.50%,3d疼痛缓解率15.00%。结论伊班膦酸钠配合放疗治疗恶性肿瘤骨转移疗效明显,起效加快。
作者 许德颖 岳峥
出处 《中国现代药物应用》 2010年第19期132-133,共2页 Chinese Journal of Modern Drug Application
  • 相关文献

参考文献4

二级参考文献21

  • 1任群,余建和,吴祥.帕米膦酸钠联合放疗治疗骨转移癌的疗效观察[J].临床肿瘤学杂志,2006,11(7):545-546. 被引量:8
  • 2Tassone P, Forciniti S, Galea E, et al. Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines [ J ]. Leukemia,2000,14(5) :841.
  • 3Wood J, Bonjean K, Ruetz S, et al. Novel antiangiogenic effects of the bisphosphonate compound zoledronic acid [ J]. JPharmacol Exp Ther ,2002,302(3 ): 1 055.
  • 4Kunzmann V, Bauer E, Feurle J, et al. Stimulation of gammadelta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma[J]. Blood ,2000,96(2) :384.
  • 5Barille S, Akhoundi C, Collette M, et al. Metalloproteinases in multiple myeloma: production of matrix metalloproteinase - 9(MMP - 9), activation of ProMMP - 2, and induction of MMP - 1 by myeloma cells[J]. Blood, 1997,90(4):1 649.
  • 6Aparicio A, Gardner A, Tu Y, et al. In vitro cytoreductive effects on multiple myeloma cells induced by bisphosphonates [J]. Leukemia, 1998,12(2) :220.
  • 7Dunford JE, Thompson K, Coxon FP, et al. Structure - activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogencontaining bisphosphonates[J]. J Pharmacol Exp Ther , 2001,296(2) :235.
  • 8Frith JC, Monkkonen J, Auriola S, et al. The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis[J]. Arthritis Rheum,2001,44(9):2 201.
  • 9Lahtinen R, Laakso M, Palva I, et al. Randomised, placebocontrolled multicentre trial of clodronate in multiple myeloma.Finnish leukaemia group [ J ]. Lancet, 1992, 340 ( 8 827 ):1 049.
  • 10McCloskey EV, Dunn JA, Kanis JA, et al. Long - term follow - up of a prospective, double - blind, placebo - controlled randomized trial of clodronate in multiple myeloma [ J ]. Br JHaematol,2001,113(4): 1 035.

共引文献2

同被引文献8

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部