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人胰岛素类似物(Insulin Aspart)持续皮下注射治疗2型糖尿病 被引量:24

Continuous subcutaneous injection of human insulin analog (Insulin Aspart) treats type 2 diabetes mellitus
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摘要 观察持续皮下胰岛素注射治疗(CSII)2型糖尿病。在给予短效胰岛素(Novolin R,42例)和给予人胰岛素类似物Insulin Aspart(46例)的5 d治疗中,2组在血糖控制上差异无统计学意义,InsulinAspart用量明显少于Novolin R。在CSII治疗2型糖尿病中,Insulin Aspart与Novolin R均安全有效,InsulinAspart用量少,优于Novolin R。 The effect of continuous subcutaneous insulin injection (CSII) treatment in type 2 diabetic patients was observed. Forty-six cases and 42 cases were treated with Insulin Aspart (human insulin analogue) and Novolin R (human insulin) for 5 days, respectively. There was no difference in controlling blood glucose between two groups. Both Novolin R and Insulin Aspart during CSII treatment in type 2 diabetes were safe and efficient. The doses of Insulin Aspart were significantly lower than those of Novolin R, thus, it seems that the former was more efficient than the latter.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2005年第3期278-279,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 人胰岛素类似物 持续皮下注射 2型糖尿病 血糖控制 药物治疗 Diabetes mellitus, type 2 Insulin infusion systems Insulin Aspart
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参考文献3

  • 1Greenspan FS, Strewler GJ. Basic Clinical, Endocrinology (5th ed). Appelton ﹠Lange,1999,666.
  • 2Ottesen JL, Nilsson P, Jami J, et al, The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model.Diabetologia, 1994,37:1178-1185.
  • 3Home PD, Lindholm A, Hylleberg B, et al . Improved glycemic control with insulin aspart: a multicenter randomized double-blind crossover trial in type 1 diabetic patients. UK Insulin Aspart Study Group. Diabetes Care,1998,21:1904-1909.

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