摘要
目的 探讨多发性硬化颈髓的扩散张量成像(diffusion tensor imaging, DTI)的可行性及临床应用价值。方法 采用平面回波成像技术对36例健康志愿者和12例多发性硬化患者行颈髓的扩散张量成像检查,并测量其表观扩散系数(apparent diffusion coefficient, ADC)值、各向异性分数(fractional anisotropy, FA)值、第1 本征值(λ1)、第2 本征值(λ2)及第3本征值(λ3)。结果 ADC图与FA图均能显示多发性硬化患者颈髓之异常信号区,其ADC值为(1473.7±227.8)×10-6mm2/s,FA值为(467.83±43.66)×10-3,λ1 值为(2024.1±283.3)×10-6 mm2/s,λ2 值为(1151.8±146.1)×10-6mm2/s,λ3 值为(1231.0±360.9)×10-6mm2/s,2λ1/(λ2 +λ3)值为1.73±0.22。多发性硬化患者颈髓病变区的ADC、λ1、λ2、λ3 值明显高于正常组(P<0.05),其FA值与2λ1/(λ2+λ3)值明显低于正常组(P<0.05),λ1 与λ2、λ3 值之间有显著性差异(P<0.05),λ1 大于λ2 与λ3。结论 DTI是一种显示颈髓多发性硬化的可靠检查手段,其病变区各向同性扩散明显增高,其各向异性扩散明显减低;颈髓病变区仍保持了各向异性,呈柱状扩散。
Objective To investigate the capacity and clinical application of diffusion tensor imaging (DTI) in multiple sclerosis (MS) of the cervical spinal cord. Methods DTI of cervical spinal cord was performed in 36 healthy volunteers and 12 cases with MS using SE-EPI. Apparent diffusion coefficient (ADC), fractional anisotropy (FA), λ_1, λ_2, and λ_3 values were measured. Results Both ADC and FA maps were able to show abnormal signal intensities of MS. ADC value in MS was (1473.7±227.8 )·10 -6 mm 2/s, FA value was (467.83±43.66)×10 -3 , λ_1 was (2024.1±283.3)×10 -6 mm 2/s, λ_2 was (1151.8±146.1)×10 -6 mm 2/s, λ_3 was (1231.0±360.9)×10 -6 mm 2/s, and 2λ_1/(λ_2+λ_3) was 1.73±0.22, respectively. The values of ADC, λ_1, λ_2, λ_3 of the MS were significantly higher than those of the control group ( P <0.05), and the values of FA and 2λ_1 /(λ_2+λ_3) decreased significantly compared with those of the control group ( P <0.05). The λ_1 was significantly higher than λ_2 and λ_3 ( P <0.05). Conclusion DTI of the cervical spinal cord is a reliable tool in demonstrating the lesions of MS, in which isotropy diffusion increases evidently and anisotropy diffusion decreases obviously and diffusion shows cylindrically symmetric anisotropy characteristics.
出处
《中国医学影像技术》
CSCD
北大核心
2005年第5期703-706,共4页
Chinese Journal of Medical Imaging Technology
关键词
脊髓
多发性硬化
磁共振成像
扩散
Spinal cord
Multiple sclerosis
Magnetic resonance imaging
Diffusion
