摘要
目的探讨磁共振扩散张量成像(DTI)在检测临床前期青光眼视射病变中的应用价值。方法对15名健康志愿者(男10名,女5名)及20例青光眼患者(男14例,女6例)行3.0 T MR DTI扫描,扩散梯度场选择32方向,利用计算机软件进行图像后处理,重建视放射纤维束、表观扩散系数(ADC)图及各向异性分数(FA)图,比较青光眼患侧、健侧及正常组视射纤维束平均长度与平均密度、ADC值、FA值。采用单因素方差分析及q检验,以P<0.05作为具有显著性差异的标准。结果青光眼患侧平均纤维束长度(mm)、平均纤维束密度、FA值、ADC值分别为:48.56±2.41、8.54±1.86、0.37±0.06、986.74±113.53;健侧分别为:89.76±12.13、15.12±1.21、0.56±0.01、885.53±97.27;正常组分别为:90.92±11.26、14.87±2.34、0.61±0.02、896.21±112.46。健侧与正常组比较各参数差异无统计学意义(P>0.05);青光眼患侧与健侧及正常组比较,视射纤维束平均长度明显减小,平均密度明显减低,差异有显著统计学意义(P<0.01);青光眼组FA值明显减小,ADC值明显升高,差异有显著统计学意义(P<0.01)。结论 MR DTI可作为临床前期青光眼视射病变的可靠评价技术。
Objective This study aims to evaluate the clinical value of MR-DTI in optic radiations of glaucoma. Meth- otis MR-DTI was performed in 20 patients suffering from unilateral glaucoma and 15 healthy subjects. The parameters of MR-DTI, including fractional anisotropy （FA） , apparent diffusion coefficient （ADC） value of optic radiations of glaucoma were evaluated. The average length of fibers and mean fibers/voxel, ADC and FA values in healthy subjects, affected nerve and unaffected nerve in glaucoma were compared. Results The ADC values in affected optic radiations were higher and FA values were lower than that in unaffected optic radiations and control optic radiations, which had statistically significant difference （ P 〈 0.01 ）. Average fiber length and mean fibers/voxel in affected optic radiations were lower than that in unaf- fected optic radiations and control optic radiations （ P 〈 001 ）. Conclusion Potential neuropathology changes occurr in the optic radiations of patients with glaucoma. MRI-DTI is a useful method in studying optic radiations damage of glaucomawhich provides more information for guiding the clinic diagnosis of glaucoma.
出处
《临床放射学杂志》
CSCD
北大核心
2013年第10期1411-1414,共4页
Journal of Clinical Radiology
关键词
扩散张量成像
视放射
青光眼
Diffusion tensor imaging Optic radiations Glaucoma
