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成都地区汉族群体抗凝血因子Ⅲ的遗传多态性 被引量:1

GENETIC POLYMORPHISM OF ANTITHROMBIN Ⅲ IN THE HAN POPULATION, CHENGDU, CHINA
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摘要 用等电聚焦免疫固定技术,调查成都地区225名无血缘关系汉族男女青年血浆抗凝血因子Ⅲ(ATⅢ)表现型的分布,发现B、AB两种普遍型和一种BV变异型;推算出ATⅢ的基因频率,即ATⅢ*A=0.1022,ATⅢ*B=0.8956,ATⅢ*V=0.0022。该遗传标记在中国人群中的频率分布系国内首次报道。 225 EDTA-plasma specimens collected from the Han population, Chengdu, China, were typedfor the phenotypes of antithrombin Ⅲ (ATⅢ) using isoelectrofocusing followed by immunofixation.Two common phenotypes, ATⅢ B, AB, and a variant ATⅢ BV were disclosed. The allelefrquencies of ATⅢ were: ATⅢ * A = 0. 1022, ATⅢ * B= 0. 8956, ATⅢ * V = 0. 0022. This isfirst reported in China.
出处 《中国法医学杂志》 CSCD 1994年第1期1-3,共3页 Chinese Journal of Forensic Medicine
基金 国家自然科学基金!39300072 纽约中华医学基金
关键词 抗凝血因子Ⅲ 等电聚焦 遗传多态性 变异型 Antithrombin Ⅲ Isoelectric focusing Genetic polymorphism
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  • 1Toshinori Nishigaki,Keiichi Omoto. Genetic polymorphism of human plasminogen in Japanese: Correspondence of alleles thus far reported in Japanese and difference of activity among phenotypes[J] 1982,The Japanese Journal of Human Genetics(4):341~348
  • 2Shigeki Nakamura,Kazue Abe. Genetic polymorphism of human plasminogen in the Japanese population: New plasminogen variants and relationship between plasminogen phenotypes and their biological activities[J] 1982,Human Genetics(1):57~59

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