摘要
目的探讨正畸力及炎性刺激影响牙周组织改建的联合效应。方法选用96只雄性SD成年大鼠,分别建立实验性牙周炎大鼠和注射内毒素健康大鼠模型,近中移动两模型的上颌磨牙。结果在0h、2h、12h、2d、7d、14d时,磨牙近中压力侧牙周膜组织内肿瘤坏死因子α(TNF_α)的蛋白表达出现波动,2d时平均光密度(OD)值达到峰值。结论急、慢性牙周炎症均可阻碍正畸力效应下的牙周组织改建,研究提示对成年牙周炎患者,牙移动应谨慎进行。
Objective To explore the combined effects of orthodontic force and inflammation on the remodelling of periodontal tissues.Methods The upper first molars underwent mesial orthodontic force on 48 rats suffering experimental periodontitis and 48 rats injected lipopolysaccharide, respectively.Results The TNF_α protein expression in the compressed periodontal tissues fluctuated during 0,2,12 hours and 2,7,14 days stages, the OD value got to the peak in the compressed periodontal tissues in 2 days.Conclusion The mechanical remodelling effects were hindered due to the circumstance of acute or chronic inflammation. The research suggests that the orthodontic treatment to adult patients with periodontal inflammation should be taken carefully.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
2005年第3期208-210,共3页
West China Journal of Stomatology
基金
高等学校博士学科点专项科研基金资助项目(20020610063)
关键词
牙周炎症
正畸力
改建
肿瘤坏死因子Α
periodontal inflammation
orthodontic force
remodelling
tumor necrosis factor α
