摘要
目的建立正畸牙移动的实验动物模型。方法选用40只7周龄雌性SPF级Wistar大鼠,每只大鼠上颌左右两侧分别为实验侧和对照侧。对照侧不做处理;实验侧用传统(不采用任何固位方法)和改进(粘结剂联合磨沟固位法)两种方法安装以两个上颌切牙为支抗,近中移动上颌第一磨牙的正畸牵引装置,并对两种方法的装置脱落率进行比较。结果采用传统方法建立的牙移动动物模型,装置脱落率为95%;改进后的牙移动装置只有1例发生脱落,脱落率为2.6%,且实验侧上颌第一磨牙发生了明显近中移动。结论以Wistar大鼠为实验对象,采用改进的粘结剂联合磨沟固位法安装以上颌切牙为支抗,近中移动上颌第一磨牙的正畸牵引装置可行,可建立正畸牙移动实验动物模型。
Objective To establish an animal model for research of orthodontic tooth movement. Methods The experiment was carried out on forty SPF female Wistar rats, which were 7 weeks old. The left side of jaws of each rat was set as experimental side, and the right side as control side. Nothing was done on the control side, and two different orthodontic appliances, which were traditional （without any fixation） and improved（with the binder and groove）, were used on the experiment side to move the maxillary first molar with the two central incisors as anchor. The break rates of the two appliances were compared. Results The break rate of traditional orthodontic appliance was 95%, while only one of the improved appliances was broken, and the rate was 2.6%. The movement of the maxillary first molar on the experiment sides was obvious. Conclusions Animal models with the improved orthodontic appliances on Wistar rats to move the molars with the central incisor as anchor are scientific, simple and reliable.
出处
《口腔医学》
CAS
2007年第2期64-66,共3页
Stomatology
基金
山东省自然科学基金资助项目(Y2004C13)
山东省医药卫生科技发展计划资助项目(2005HZ038)
关键词
牙移动
动物实验
大鼠
tooth movement
animal experimentation
rats
