摘要
以离子色谱法（ＩＣ）同时测定３５例正常志愿者及４５例患有消化道良性疾病或不同期癌症患者的血清铜和锌。结果显示：正常志愿者、良性疾病及Ⅰ、Ⅱ期癌症患者的血清铜、锌和铜／锌比值均无明显差异；但Ⅲ、Ⅳ期癌症患者组的血清铜（２６．５３±１．４１μｍｏｌ／Ｌ）和铜／锌比值（２．２５±０．１６）均非常显著地升高（Ｐ＜０．０１），而血清锌（１１．７８±０．４６μｍｏｌ／Ｌ）则明显下降（Ｐ＜０．０５）。表明血清铜、锌和铜／锌比值在诊断Ⅰ、Ⅱ期消化道癌症及鉴别良、恶性疾病方面并无意义，但对术前癌症分期，进而选择更好的治疗措施是有帮助的。
Serum copper and zinc were simultaneously determined by ion-exchange chromatography (IC) in 35 normal volunteers and 45 patients with benign diseases or different stage cancers of the digestive tract. No significant differences of serum Cu, Zn and Cu/Zn ratio were found among normal volunteers , patients with benign diseases and those with stage Ⅰ or Ⅱ cancers, while in the group of stage Ⅲ and Ⅳ cancer patients, serum Cu (26. 53±1. 41μmol/ L)and Cu/Zn ratio(2. 25±0. 16) were very significantly elevated(P<0.01) and that of serum Zn(11. 78±0. 46μmol/L) was remarkably decreased (P<0.05). Our results showed that serum Cu , Zn and Cu/Zn ratio were of no help in detecting early stage cancers and in differentiating them from benign diseases but were useful in predicting stages of cancers before operation for a better choice of therapy.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1994年第1期54-57,共4页
Acta Academiae Medicinae Sinicae
基金
美国谢氏癌症基金
中国国家自然科学基金
关键词
血清
铜
锌
消化系肿瘤
离子色谱法
serum copper serum zinc digestive system neoplasms ion-exchange chromatography
