摘要
通过测定大鼠红细胞膜荧光偏振度P和N A DH-细胞色素c氧化还原酶的变化,研究kappa-硒化卡拉胶对红细胞膜流动性和封闭度的影响。结果表明,kappa-硒化卡拉胶140mg·kg^(-1)·d^(-1)×30 d可显著降低大鼠红细胞膜荧光偏振度,即可显著提高细胞膜流动性(P<0.05),ig 140及70 mg·kg^(-1)·g^(-1)×30d可显著提高大鼠红细胞膜封闭度(P<0.05)。
Effects of kappa-selenocar-rageenan (k-SeC) on membrane fluidity and ghost reseal ability of rat erythrocyte were studied by measuring the fluorescence polarization and the NADH-cytochrome C oxido-reductase, respectively. After rats were given ig K-SeC 140 mg ·kg-1 ·d-1 × 30 d , the fluorescence polarization was decreased in comparison with saline control group (P<0. 05). It suggested that K-SeC increased the membrane fluidity. The reseal ability of erythrocyte membrane (ghost) was also elevated after ig K-SeC 140 and 70 mg ·kg-1 ·d-1 × 30 d (P < 0.05).
出处
《中国药理学报》
CSCD
1994年第3期211-214,共4页
Acta Pharmacologica Sinica
关键词
硒
角叉菜胶
红细胞膜
膜流动性
selenium
carrageenan
fluo- rescence polarization
erythrocyte membrane
blood viscosity
membrane fluidity
cyto- chrome C oxidase
