摘要
本实验系统地研究了４－硒（代）硫酸酯多糖的抗肿瘤免疫调节作用及其机制。发现该药在体内外均有抑制肿瘤生长的作用，并认为其抑瘤机制与促进巨噬细胞活性，间接促进淋巴细胞活性，释放具有杀伤肿瘤细胞的效应分子以及选择性抑制肿瘤细胞大分子合成有关。结果表明，４－硒（代）硫酸酯多糖是一种兼具杀伤肿瘤细胞和增强免疫功能双重作用的新型免疫型抗肿瘤药。
We have systematically observed in the present study the anticarcinogenic and immunomodulatory effects of 4-Seleno-carageenan(Se-carra)as well as their possible mechanisms of actions in vivo and in vitro. It was found that se-carra had inhibitory effects on tumor growth in vivo and in vitro. The underlying mechanisms of this tumor suppresslive effect may be related with the activation of macrophages,followed by the indirect priming of lymphocytes to release effector molecules such as IL-2,to express IL- 2 receptors,and to selectively suppress,the synthesis of macromolecules in tumor cells.The results imply that Se-carra has dual functions of tumor cell-killing effect and immunostimulating effect,therefore may serve as a novel immuno-cytotoxic anticarcinogenic drug.
出处
《生理科学进展》
CAS
CSCD
北大核心
1996年第1期43-46,共4页
Progress in Physiological Sciences
关键词
4-硒(代)
硫酸酯多糖
免疫调节
抗癌药
药理学
Seleno-carrageenan
Chemical prevention of tumor
Immunomedulation
Immunoactive cells
Tumor immunity
