摘要
目的 通过对孕18～2 0w的中期妊娠妇女筛选出有可能发生先兆子痫的高危孕妇,口服小剂量阿斯匹林,探讨小剂量阿斯匹林预防先兆子痫的疗效。方法 采用前瞻性随机双盲对照研究,对孕18～2 0w中期妊娠妇女筛选出10 0例高危孕妇随机分为2组:治疗组口服小剂量阿斯匹林(10 0mg/d) ,对照组口服维生素C(0 .4g/d) ,观察孕晚期先兆子痫的发生率。结果 治疗组妊高征发生率4 % ,显著低于对照组妊高征的发生率为2 4 %。两组宫内发育迟缓、产后出血、胎盘早剥、早产的发生率统计学上无差异。结论 小剂量阿斯匹林可有效地预防高危孕妇先兆子痫的发生,而对围产期母儿的健康无不良影响。
Objective: To assess the effect of low-dose aspirin for prevention of pre-eclampsia when given to women identified as high risk 18 to 20 weeks' gestation. Methods: We conducted a prospective randomized, single blind ,controlled clinical trial in 100 pregnant women at high risk of pre-eclampsia .From the 18th to 20th week of gestation onward, low-dose aspirin (100mg daily)(study group,n=50) or vitaminum C (0.4g daily)(control group,n=50)was given consecutively for the 36th week. Results: The incidence of pre-eclampsia in the study group (4%) was significantly lower than those in the control group (24%). No effect of low dose aspirin on both mother and fetus were observed . Conclusion: low dose aspirin administration beginning at early stage of the 18th-20th week in high-risk pregnant patients may improve the fetoplacental circulation and thus prevent preeclampsia effectively.
出处
《中国优生与遗传杂志》
2005年第5期68-69,共2页
Chinese Journal of Birth Health & Heredity
