摘要
目的:针对有子痫前期(PE)高危因素的孕妇,探讨孕20周后应用小剂量阿司匹林(LDA)对预防PE及妊娠结局的影响。方法:采用随机、开放前瞻性临床分析法,根据患者的自愿原则,选择孕周超过20周且有PE高危因素的孕妇,按照不同治疗方法分为2组:研究组(20例)口服LDA 75 mg/d直至分娩;对照组(33例)不服用LDA,观察两组PE发生率及母儿妊娠结局。结果:研究组PE发生率(40.0%)显著低于对照组(69.7%),研究组早产发生率(25.0%)显著低于对照组(60.6%),两组比较差异均有统计学意义(P<0.05)。研究组与对照组相比,分娩孕周有延长趋势,平均新生儿出生体质量增加,但差异无统计学意义(P>0.05);两组PE发生孕周、剖宫产率等比较,差异无统计学意义(P>0.05);两组胎儿生长受限、胎儿窘迫、胎盘早剥、产后出血等并发症发生率比较,差异无统计学意义(P>0.05)。结论:孕20周后应用LDA可有效预防高危孕妇发生PE,且可降低早产发生率。
Objective：To investigate the effectiveness of low dose aspirin（LDA） to prevent preeclampsia and influence the pregnancy outcomes when given to women with high risk of developing to preeclampsia at later than 20 weeks＇gestation. Methods. We conducted a block randomized, open, prospective clinic analysis, chose data from pregnant women voluntarily who were at high risk of preeclampsia. According to the therapeutic method, those pregnant women were divided into two groups..20 women in the study group were given LDA 75mg/d till delivery ,33 women in the control group without any LDA. The incidence of preeclampsia and pregnancy outcomes were observed. Results.The incidence of preeclampsia was 40.0% in the study group, which was significantly lower than the rate of 69.7% in the control group （ P 〈 0.05） ; the rate of preterm birth in the study group （25.0%） was pronouncedly lower than those in the control group （60.6%） （ P 〈 0. 05）. Compared with control group ,the delivery gestation was extended in the study group, with an elevation of the average newborn weight, though without any statistical difference（ P 〉 0.05） ;there was no significant difference in the gestation age of developed preeclampsia,the rate of cesarean section between the two groups（ P 〉 0.05 ）. There was no significant difference on the incidence of fetal growth restriction, fetal distress, placental abruption, postpartum hemorrhage and other complications between the two groups（ P 〉 0.05）. Conclusions：The treatment of low dose aspirin in high-risk pregnant patients after 20 weeks of gestation also can significantly prevent preeclampsia and reduce the incidence of premature birth.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2016年第12期913-916,共4页
Journal of Practical Obstetrics and Gynecology
基金
国家自然科学基金(编号:81501257
81501341)
江苏省自然科学基金(编号:BK20140082)
关键词
小剂量阿司匹林
子痫前期
早产
妊娠结局
Low dose aspirin
Preeclampsia
Premature birth
Pregnancy outcomes
