摘要
应用牛磺胆酸钠诱发大鼠急性出血坏死性胰腺炎并发肺损伤模型，动态观察血中ＴＸＢ＿２、６－酮－ＰＧＦ＿１ａ及ＬＰＯ含量变化并观察川芎嗪的影响。结果表明：随着肺损伤程度加重，血浆ＴＸＢ＿２含量、ＴＸＢ＿２／６－酮－ＰＧＦ＿１ａ比值，ＬＰＯ含量渐增高，肺系数值也增加；川芎嗪能显著降低ＴＸＢ＿２和ＬＰＯ含量，稳定ＴＸＢ＿２／６－酮－ＰＧＦ＿１ａ比值，降低肺系数值，改善肺组织病理形态变化，从而提高存活率。
Changes of PGI_2,TXA_2 and LPO levels and the effects of tetramethylpral-zine were studied in a model of lung injury following sodium taurocholate-inducedacute haemorrhagic necrotizing pancreatitis in rats. The results suggested that followed thedeepening of lung injury the value of plasma TXB_2、TXB_2/6-Keto-PGF_1a and SerumLPO as well as lung index were elevated progressively. Tetramethylpraizine caused amarked decrease in both the level of TXB_2,ratio of TXB_2/6-Keto-PGF_1a,and the lungindex. It improved the pathologic changes and survival rate. It was concluded that TxA_2,PGI_2 and oxygen free radicals play an important role in the pathophysiology Of lunginjury in acute haemorrhagic necrotizing pancreatitis in rats and tetramethylpraizine hastherapeutic effects in that case through maintaning the balance of TXA_2 /PGI_2 andscavenging oxygen free radical.
出处
《中国病理生理杂志》
CSCD
北大核心
1994年第1期64-67,共4页
Chinese Journal of Pathophysiology
关键词
胰腺炎
呼吸窘迫
综合征
前列腺素
Pancreatitis
Respiratory distress syndrome
Prostaglandins
Free radicals
